Part of the PACT mission is to promote interest in cellular therapy/engineering among physicians and scientists-in-training and to prepare interested individuals for academic careers in cellular therapy/engineering.
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University of Wisconsin - Madison, Waisman Biomanufacturing (WB)
Wisconsin Institutes for Discovery
Madison, WI
April 9, 2013
- Robert Lindblad, MD - PACT Program Overview
- Cliona Rooney, PhD - Manufacture of Natural Killer Cells as Treatment for Multiple Myeloma
- Sean Savitz, MD - Developing in-vivo Models for Stroke Indication (Presentation not available)
- Michael Matthay, MD - Clinical Cell Therapy Experience for Acute Lung Injury (Presentation not available)
- Timothy Hacker, PhD - In-vivo Animal Models of Heart Disease
- Marlowe Eldridge, MD - In-vivo Models and Cell Delivery for Lung Indications
- Peiman Hematti, MD - Mesenchymal Stem Cell Characterization
- Derek Hei, PhD - Cell Therapeutics - Process Development and Manufacturing for Human Clinical Trials
- John Centanni, MS - IND Application Process: For The New Clinical Investigator
- Christian Capitini, MD - Using Mouse Models to Optimize Cell Therapies for GVL/GVHD (Presentation not available)
- Timothy Kamp, MD, PhD - iPS cells for Cardiac Indications
Baylor College of Medicine, Center for Cell and Gene Therapy (CAGT)
Pavilion for Women
Texas Children's Hospital
Houston, Texas
Day 1 - October 22, 2012
- Robert Lindblad, MD - PACT Overview
- Adrian Gee, MI Biol, PhD - Cell Processing at CAGT
- Cliona Rooney, PhD - Challenges of Cell Culture in Manufacturing
- Juan Vera, MD - Optimization of Suspension Cell Culture
- Ann Leen, PhD - Generation of Antigen Specific T Cells
- Catherine Bollard, MD - Evaluation of T Cell Products
- David Spencer, PhD - Antigen Presenting Cells
- John Wagner, MD - Isolation and Expansion of Umbilical Cord Blood Regulatory T Cells
- Gianpietro Dotti, MD - Use of CARS
- Stephen Gottchalk, MD - Genetic Modification for Immune Evasion
- Bambi Grilley, RPh - Regulatory Concerns in Cellular Therapies
Day 2 - October 23, 2012
- Thomas Zwaka, MD - ES & IPS
- Natasha Lapteva, PhD - NK Cells for Therapy
- Peiman Hematti, PhD - Mesenchymal Stromal/Stem Cells
- Adrian Gee, MI Biol, PhD - Getting the Product to the Patient
- Helen Heslop, MD - Broadening the Application of Cellular Therapies
City of Hope, Center for Applied Technology Development
Argyros Auditorium Duarte, CA
Day 1 - November 10, 2011
- Larry Couture, PhD- Welcome and introductions
- Robert Lindblad, MD - PACT, Overview Mission
- Tina Etcheverry PhD - Critical Considerations for Bioprocessing of Stem Cells for Clinical Use (Presentation not available)
- Chang-Yi Chen, PhD - Scalable expansion of hES cells in suspension culture (Presentation not available)
- Timothy Cote, MD, MPH - Regulatory considerations: Early decisions and best practices
- Martha Reitman, MD - Getting to IND, an Academic Industrial Perspective (Presentation not available)
University of Minnesota, Molecular and Cellular Therapeutics
Continuing Education & Conference Center
St. Paul, Minnesota
Day 1 - October 26, 2010
- Debbie Wood - Meeting Overview & Objectives
- John E. Wagner, MD - Clinical Trial Design - The Art of Translational Medicine
- Jeffrey S. Miller, MD - PACT: Translational Development & Scale Up NK Cells
- John R. Ohlfest, PhD - (Presentation not available)
- Claudio G. Brunstein, MD - Adoptive Transfer of Regulatory T Cells in UCB Transplantation
- David H. McKenna, Jr., MD - Development of Potency Assays for Cellular Therapies
- Keli L. Hippen, PhD - Purity and Potency Assay Development
- Julie M. Curtsinger, PhD - Immune Monitoring for Translational Clinical Trials
- Allison Hubel, PhD - Emerging Issues in Cryopreservation of Cellular Therapies
- Diane M. Kadidlo, BS, MT (ASCP), SBB - MCT Facility Overview
Day 2 - October 27, 2010
- David H. McKenna, Jr., MD - Moving from Research to Clinical Production
- Darin J. Sumstad, BS, MT (ASCP) - Cell Culture Optimization
- Adrian P. Gee, MI Biol, PhD - Equipment and Vendor Qualification
- Fran Rabe, MS, CQM, (ASQ) - FDA Inspection and Management
National Library of Medicine
Lister Hill Center Auditorium
National Institutes of Health
Bethesda, Maryland
Workshop Booklet Day 1 - September 14, 2011
Session 1: Congenital Blood Disorders - Part 1
- Mark Walters, MD - Hematopoietic Stem Cell Transplantation for Hemoglobinopathies
- John F. Tisdale, MD - Stem Cell Gene Therapy for Hemoglobinopathies
- Sung-Yun Pai, MD - Stem Cell Gene Therapy for Immunodeficiency (Presentation not available)
- M. Louise Markert, MD, PhD - Thymus Transplantation for Complete DiGeorge Anomaly
Session 1: Congenital Blood Disorders - Part 2
- Hans-Peter Kiem, MD, FACP - Stem Cell Gene Therapy for Franconi Anemia - (Presentation not available)
- John E. Wagner - Hematopoietic Stem Cell Transplantation for Fanconi Anemia
Session 2: Neurodegenerative Diseases and Brain Injury
- Paul J. Orchard, MD - Hematopoietic Stem Cell Transplantation for Adrenoleukodystrophy
- David A. Williams, MD - Stem Cell Gene Therapy in Childhood Cerebral Adrenoleukodystrophy - (Presentation not available)
- Robert D. Steiner, MD - Neural Stem Cell Transplantation for Neuronal Ceroid Lipofuscinosis (Batten Diseases): Successes and Challenges - (Presentation not available)
- Charles S. Cox, Jr., MD - Progenitor Cell Therapies for Pediatric Traumatic Brain Injury
- Joanne Kurtzberg, MD - Can Autologous Cord Blood Correct Acquired Brain Injury in Pediatric Patients?
Day 2 - September 15, 2011 Session 3: Regenerative Medicine
- Kenneth L. Berger, PhD - Clinical Application of ESC derived Motor Neuron Progenitors (MotorGraftTM) in the Treatment of Infantile Spinal Muscular Atrophy (SMA) Type 1
- Jane S. Lebkowski, PhD - Human Embryonic Stem Cell Therapy for Spinal Cord Injury
- Jakub Tolar, MD, PhD - Transplantation for Extracellular Matrix Disorder: Problems, Premises, and Promises
- Christopher Breuer, MD - The Translation of Tissue Engineered Vascular Grafts for Use in Congenital Heart Surgery
Natcher Conference Center
National Institutes of Health
Bethesda, Maryland
Day 1 - April 23, 2009
Session 1: T-Regulatory Cells
- David H. McKenna, Jr., MD - Considerations for Clinical Manufacture of T Regulatory Cells
- Bruce L. Levine, PhD - Engineering Artificial Antigen Presenting Cells for Efficient Expansion of Regulatory T Cells
- Claudio G. Brunstein, MD - (Presentation not available)
Session 2: Mesenchymal Stem Cells
- Adrian P. Gee, MI Biol., PhD - Opening Presentation
- Ian K. McNiece, PhD - Mesenchymal Stem Cells
Mesenchymal Stem Cell Transplantation for Heart Failure - Katarina Le Blanc, MD, PhD - (Presentation not available)
Session 3: Antigen-Specific T Cells
- Shelly Heimfeld, PhD - Banking and Qualification of Feeder Cells for Clinical Production of Antigen-Specific T Cells
- Philip D. Greenberg, MD - (Presentation not available)
- Cliona M. Rooney, PhD - Antigen-Presenting Cells (APCs) for T Cell Activation
Session 4: Engineered T Cells
- Bernard A. Fox, PhD - Cell Processing Related Issues: Adoptive T Cell Immunotherapy
- Carl H. June, MD - Engineered T Cells for HIV/AIDS
- Steven A. Rosenberg, MD, PhD - Cell Transfer Therapy for Patients with Cancer
Session 5: Natural Killer Cells
- David Stroncek, MD - NK Cell Therapy: Cell Processing Considerations
- Jeffery S. Miller, MD - The Role of Haploidentical NK Cells in Cancer and Transplantation
- Richard W. Childs, MD - In Vitro Expansion of Human NK Cells for Adoptive Cancer Immunotherapy
Day 2 - April 24, 2009
Session 6: Dendritic Cells
- Theresa L. Whiteside, PhD - Dendritic Cells for Therapy: Production, Maturation and Potency
- Sharon A. Riddler, MD, MPH - Therapeutic Vaccination with Autologous Dendritic Cells in HIV Infection
- Pawel Kalinski, MD, PhD - Dendritic Cells in Cancer Immunotherapy: Induction of Tumor-homing Effector-type T cells
Session 7: Cell Trafficking and Imaging Techniques
- Marianna Sabatino, MD - Imaging and Cell Therapy
- Erin F. Simonds, PhD Candidate - (Presentation not available)
- Zhenghong Lee, PhD - (Presentation not available)
- Eric T. Ahrens, PhD - (Presentation not available)
University of Pittsburgh Cancer Institute
Immunological Monitoring and Cellular Products Laboratory
Hematopoietic Stem Cell Laboratory
Herberman Conference Center
Pittsburgh, Pennsylvania
Day 1 - May 5, 2008
- Meeting Objectives | Debbie Wood, BS, MT(ASCP)
- Facility Design - University of Pittsburgh | Theresa L. Whiteside, PhD
- Facility Design - University of Minnesota | Diane Kadidlo, MT (ASCP)
- Facility Design - Baylor College of Medicine | Adrian Gee, MIBiol, PhD
- Consideration for Optimization of Culture Conditions for Various Cell Types | Darin Sumstad, CLS
- Flow Cytometric Analysis of Cell Therapy Products | Albert Donnenberg, PhD
- Umbilical Cord Blood-Dervived T-Regulatory Cells | David McKenna, MD
- Assessments of Regulatory T cells and Other Monitoring Assays | Theresa Whiteside, PhD
- DC-based Vaccine with Autologous Inactivated HIV-1 | Sharon Riddler, MD, MPH
- Clinical-Scale Production of Natural Killer Cells for Immunotherapy | David McKenna, MD
- T Cell Therapies: The What, The Why and The How | Cliona Rooney, PhD
- CTLs for Therapy of Post-Transplant Malignancies | Diana Metes, MD
Day 2 - May 6, 2008
- Improving your Preservation Practice | Allison Hubel, PhD
- Adipose-Derived Stem Cells: Phenotype, Function, and Clinical Targets | Albert Donnenberg, PhD
- Lab Practical - CD34 Single Platform Enumeration | Deborah Griffin, MS
- Lab Practical - Endotoxin and Mycoplasma | Joanna Stanson, MS
University of Minnesota
Molecular and Cellular Therapeutics
Earle Browne Continuing Education and Conference Center
St. Paul, Minnesota
Day 1 - April 10, 2007
- Meeting Objectives | Debbie Wood, BS, MT(ASCP)
- Facility Design-University of Minnesota | Diane Kadidlo, MT(ASCP), SBB
- Facility Design-University of Pittsburgh | Deborah Griffin, BA
- Facility Design-Baylor College of Medicine | Adrian Gee, MIBiolo, PhD
- Facility Design-Mayo Clinic | Doug Padley, MT(ASCP)
- Facility Cleaning & Environmental Monitoring | Adrian Gee, MIBiolo, PhD
- Supplies and Reagents | Lisa Van Orsow, BS
- Staff Training | Deborah Griffin, BA
- Documentation and Batch Records | Joanna Stanson, MS
- CMC Writing | Dave McKenna Jr., MD
- Product Development | Karen Prezioso, MS
Day 2 - April 11, 2007
- Cryopreservation | Allison Hubel, PhD
- Data Management - Deviations & Processing | Darin Sumstad, CLS (NCA, ASCP)
- Lot Release | Diane Kadidlo, MT(ASCP), SBB
- IND - Cell Therapy | Robert Lindblad, MD, FACEP
Baylor College of Medicine
Houston, Texas
Day 1 - April 4, 2006
- Meeting Introduction & Objectives | Debbie Wood, BS, MT(ASCP)
- Facility Design-University of Pittsburgh | Deborah Griffin, BA
- Facility Design-University of Minnesota | Diane Kadidlo, MT(ASCP), SBB
- Facility Design-Baylor College of Medicine | Adrian Gee, MIBiolo, PhD
- Facility Design-MD Anderson Cancer Center | John McMannis, PhD
- Facility Cleaning & Monitoring | Adrian Gee, MIBiolo, PhD
- Facility and Equipment Maintenance | Deborah Griffin, BA
- Supplies and Reagents | Lisa Van Orsow, BS
- Documentation | Adrian Gee, MIBiolo, PhD
- Labeling | Jeff Wilson, BS
- Databases | Darin Sumstad, CLS (NCA, ASCP) and Jeff Wilson, BS
Day 2 - April 5, 2006
- Production Records & Documentation | Diane Kadidlo, MT(ASCP), SBB and Joanna Stanson, MS
- Product Testing & Release | Diane Kadidlo, MT(ASCP), SBB
- Staff Training | John McMannis, PhD
Preservation of Cellular Therapies
Dates: May 18 - 19, 2020**
Location: Minneapolis, MN and simultaneous webcast
Course Home Page
Flyer
**While the dates to particpate live have passed, the recorded course lectures and packet remain available for online viewing. Registration for the online course closes October 31st, 2020. See the Course Home Page for registration details.
Lecture topics:
- Fundamentals of cryopreservation including mechanism of damage and strategies to prevent damaging cells during freezing, storage and warming,
- Step-by-step protocol development including methods by which to construct a new preservation protocol and debugging an old protocol that is no longer working well,
- Equipment, reagents and supplies used in preservation,
- The challenges in implementing preservation in a clinical/GMP environment,
- Fundamentals of quality control (QC) and quality assurance (QA) as well as application of the program to preservation,
- Design and operation of a storage facility for cryopreserved cells,
- Regulatory issues associated with preservation of a therapeutic product,
- Emerging technology and approaches for the preservation of cells.
Audience:
The course is designed for a wide range of participants. The preservation of cells has applications in the fields of recombinant cell biotechnology, cell banking, cell therapy, regenerative medicine, and cell-based assays, for example. Previous attendees have ranged from manufacturing engineers, laboratory managers, technicians, nurses, and scientists, and several companies have used the course as standard training for their employees. The course material is designed for those who have little experience with preservation, as well as those proficient in preservation who is interested in improving their practices.
Speakers:
Allison Hubel, PhD is Professor of Mechanical Engineering and Director of the Biopreservation Core Resource (BioCoR, www.biocor.umn.edu), a national resource in biopreservation.
Diane Kadidlo received her B.S. from Iowa State University. She has served as the Supervisor for the University of Minnesota Medical Center Clinical Cell Therapy Laboratory since 1996 overseeing the production of cell and tissue products.
David McKenna, MD is a Professor of Laboratory Medicine & Pathology at the University of Minnesota where he holds the American Red Cross Chair in Transfusion Medicine. He is the Scientific and Medical Director of Molecular & Cellular Therapeutics.
Ian M Pope, PhD, MBA, BSc is the Global Director of Cryo Solutions at Brooks Life Sciences. Ian has worked in the area of cryogenic systems for over 25 years, His expertise lies in the area of the practical application of cryogenics to the storage and preservation of biological materials.
Fran Rabe has over 20 years of experience working in the areas of tissue and cell quality assurance and regulatory compliance. She currently oversees the quality assurance aspect of operations at the University of Minnesota Molecular and Cellular Therapeutics (MCT) Facility.
Quick links:
Questions? Contact us at biocor-pct@umn.edu